Flaviviruses constitute a family of linear, single-stranded RNA(+) viruses. They cause approximately 70 different diseases which have a major impact on national economies and health authorities worldwide.
This book reviews the most significant cutting edge discoveries in the flavivirus field. Aspects of molecular biology common to flaviviruses are explored in depth. Topics include the evolution and function of flavivirus RNA, flavivirus replication, laboratory diagnosis and vaccine development. Individual chapters are devoted to the molecular biology of yellow fever virus, dengue virus, Japanese encephalitis virus, and hepatitis C virus. This book is essential for all flavivirus researchers and a recommended text for all virology laboratories.
Table of Contents
1. The Molecular Biology of Yellow Fever Virus 2. Title: Taxonomy and Evolution of the Flaviviridae 3. Origin, Evolution and Function of Flavivirus RNA in Untranslated and Coding Regions: Implications for Virus Transmission 4. Cis and Transacting Determinants of Flaviviridae Replication 5. A New Approach to Dengue Epidemiology. Sequential Infection and ADE Hypothesis: The Story of a Dogma 6. Functional Role of prM Glycoprotein in Dengue Virus Replication 7. Diagnosis of Dengue Virus Infection 8. Japanese Encephalitis Virus: Molecular Biology and Vaccine Development 9. Evolution, Epidemiology and Control of the Japanese Encephalitis Virus 10. Maturation and Assembly of Hepatitis C Virus Core Protein 11. Molecular Virology and Pathogenesis of Hepatitis C 12. Treatment of HCV-Related Liver Diseases and Prevention of Hepatocellular Carcinoma 13. A New Perspective in the Pathophysiology of Hepatitis C Virus (HCV) Infection: Interaction of the NS3 Protein of HCV With Serine-/Threonine-Specific Protein Kinases