Glycomics (a comprehensive study of glycans, often denoted as the third alphabet of molecular biology, besides nucleic acids and proteins) relies on techniques that use "heavy machinery", such as mass spectrometry, liquid chromatography, and capillary electrophoresis. The use of biosensors and biochips for glycan analysis offers the possibility of lower costs, lower time and sample consumption, and ease of use. This highly interdisciplinary book introduces students, researchers, and professionals to the broad scope of this area, including the basics of nanotechnology and materials science, glycomics, and bioanalytical chemistry, as well as several historical facts, contexts and future perspectives. The introductory chapters are utilized in the book later for the state-of-the-art chapters on glycan-based diagnostics and imaging, enrichment techniques, and therapy, which makes this book unique and of great interest to a wide audience. The authors are skilled specialists and research scientists with many years of experience in this area and former investigators on a prestigious European Research Council Starting Grant.
Table of Contents
Introductory Nanotechnology: What Is So Special about the Nanoscale? Introduction to Glycomics and Glycan Analysis. Bioanalytical Methods. Functional Nanomaterials in Sensing and Biosensing Applications . Simulation of Different Biosensors using MatLab. Self-Assembled Monolayers for Surface Modification. Introduction to Glycan Enrichment Using Nanomaterials. Glyconanobiotechnology for Medical Applications.
Tomáš Bertók is a research scientist at the Institute of Chemistry, Slovak Academy of Sciences, Slovakia. His research is focused on assay development and medical diagnostics of different diseases using nanotechnology, (bio)sensors, and surface modifications for glycomics. He is a recipient of numerous national and international awards and individual grants, including Top Student Personality of Slovakia (2014), an award from the president of Slovakia for research in life sciences (2014), Forbes Slovakia 30 under 30 (2016), Slovakia’s Young Scientist of the Year (2016), and the Danubius Young Scientist Award from the Austrian Ministry of Science, Research and Economy (2016). Dr. Bertók has published over 38 original papers with more than 700 citations, 3 book chapters, and 1 book for the popularization of nanobiotechnologies among high school and university students, and co-founded a diagnostic startup, Glycanostics.