Dementia and Motor Neuron Disease is a single authoritative reference on the current understanding of frontotemporal dementia in amyotrophic lateral sclerosis (ALS). This comprehensive work is ideal for clinical and research groups focusing on dementia or ALS, as well as those working in the fields of neuroimaging and neuropsychology.
Key topics covered include:
• Frontotemporal dementia, including history, anatomy and impairment
• Clinical phenomenology and treatment
• Neuropathological, cognitive dysfunction and altered cognition spectrums
• Molecular and cellular neuropathology
With contributions from international opinion leaders in dementia and motor neuron disease, this is a one-of-a-kind reference for established clinicians and researchers, as well as graduate students studying neurodegeneration.
Table of Contents
Foreword by Andrew Kertesz 1. Frontotemporal Dementia in ALS: Lessons from History 2. Frontotempotral Dementia – Current Concepts 3. Clinical Phenomenology and Treatment of Frontotemporal Dementia 4. The Clinical and Pathological Spectrum of ALS 5. Identification and Categorization of Frontotemporal Impairment in ALS 6. The Spectrum of Altered Cognition in Amyotrophic Lateral Sclerosis 7. The Spectrum of Cognitive Dysfunction in ALS/MND in the Japanese Population 8. Primary Lateral Sclerosis: Cognitive, Language, and Cerebral Hemodynamic Findings 9. The Anatomic Basis of Symptoms in Frontotemporal Dementia 10. Neuroimaging in ALS and ALS with Frontotemporal Dementia 11. New Approaches to Imaging in ALS 12. Neuropathology of Frontotemporal Lobar Degenerations 13. Molecular and Cellular Neuropathology of Cognitive Dysfunction in ALS 14. Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of Guam 15. Neuropathology of the Japanese Variants of FTD/ALS 16. The Genetics of Frontotemporal Dementia 17. Frontotemporal Dementia and the Involvement of Tau 18. Altered Tau Protein Metabolism in Amyotrophic Lateral Sclerosis with Cognitive Impairment 19. Frontotemporal Syndromes in the Motor Neuron Diseases
Michael J Strong MD FRCPC is Professor and Co-Chair, Department of Clinical Neurological Sciences, University of Western Ontario and Scientist, Cell Biology Research Group, Robarts Research Institute, London, ON, Canada