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Cytokine Gene Polymorphisms in Multifactorial Conditions




ISBN 9780849336195
Published June 21, 2006 by CRC Press
488 Pages - 45 B/W Illustrations

 
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Book Description

The literature on cytokine genetics is vast, so vast that it is now practically beyond the time or logistical constraints of most scientists to successfully keep pace with it. A compilation of the latest research, Cytokine Gene Polymorphisms in Multifactorial Conditions brings together, reviews, and structures up-to-date information on polymorphisms in cytokine genes. It discusses haplotype structures and linkage disequilibrium patterns in cytokine gene loci; functional biological effects of polymorphisms; and genetic associations with disease. The book documents polymorphisms in the most important cytokine genes, or gene clusters, and their biological and genetic effects in a multitude of distinct multifactorial conditions.

Unique to this book are the "disease-centered" chapters examining the role of cytokine gene polymorphisms in a multitude of multifactorial conditions. The conditions include autoimmune or chronic inflammatory diseases, cardiovascular disease, infectious diseases, and longevity. "This section is a real tour de force" (Grant Gallagher and Michael F. Seldin, March 2006).

Broadening the understanding of the effect of genetic variations on human immune responses, the organization, scope, and content of this book make it a valuable and easily accessible resource. The book integrates genetic, immunological, and clinical information and will serve as a reference for novice and expert geneticists, immunologists, cell biologists and clinicians. It is a must for everyone involved in, or planning, cytokine genetics or immunogenetics studies.

Table of Contents

GENERAL CONCEPTS
The Biology of Cytokines:General Principles, Properties and Lessons from Animal Models, D. Agnello and M. Gadina
Genetics of Multifactorial Disorders, J.R. Oksenberg and J.D. Rioux
Statistical Approaches to Analysis of Polymorphisms in Multifactorial Conditions, A. Goris and M. de Andrade
Introduction to Integrated Bioinformatic Resources for Cytokine Genetics Research, R. Lazarus
Cytokine Gene Nucleotide Sequence Alignments, J. Bidwell
SNP Genotyping Techniques, P.-Y. Kwok

CYTOKINE GENE POLYMORPHISMS
The IL1 Cluster, T. Pessi, C. Eklund, A. Raitala, and M. Hurme
IL-2 Biology and Polymorphisms in Multifactorial Conditions, F. Matesanz, M. Fedetz, and A. Alcina
The Chromosome 5q23.1 -q31.1 Cluster of Cytokines, T. Laitinen
IL10, R. Lazarus
The IL19 Subfamily of Cytokines, S. Kõks, K. Kingo, E. Vasar, and H. Silm
The IFNG -IL26 -IL22 Cytokine Gene Cluster, K. Vandenbroeck and A. Goris
TNF-a Polymorphisms and Disease, R.M. Gorczynski and I. Boudakov
Macrophage Migration Inhibitory Factor (MIF), Z. Alourfi, D.W. Ray, and R. Donn
Polymorphisms of Chemokines and Their Receptors, B. Puissant, C. Combadière, and E. Lavergne

POLYMORPHIC CYTOKINE NETWORKS IN MULTIFACTORIAL CONDITIONS
Asthma and Atopy, J. Karjalainen, M. Virta, K. Ädjers, and M. Hurme
Common Rheumatic Diseases, R. Kilding and A.G. Wilson
Systemic Lupus Erythematosus, S. D 'Alfonso
Sjögren 's Syndrome, M. Pertovaara
Multiple Sclerosis, O.H. Kantarci and B.G. Weinshenker
Type 1 and 2 Diabetes, R. Bergholdt and F. Pociot
Psoriasis, S. Kõks, K. Kingo, E. Vasar, and H. Silm
Diseases of the Gastrointestinal Tract, T. Höhler
Pulmonary Fibrosis, B. Yucesoy and M.I. Luster
Atherosclerosis, G. Candore, S. Vasto, G. Colonna-Romano, D. Lio, M. Carusob, I.M. Rea, and C. Caruso
Longevity, I.M. Rea, G. Candore, L. Cavallone, F. Olivieri, M. Cardelli, C. Franceschi, G. Colonna-Romano, D. Lio, O.A. Ross, and C. Caruso
AIDS, A. Vasilescu, H. Do, and J.-F. Zagury
Tropical Infectious Diseases, T. Quirico-Santos, A.M. Da-Cruz, C. Fernandez Kubelka, J. Lannes-Vieira, and M. Ozório Moraes
Suseptibility to Infection and Severe Disease in Schistosomiasis, V. Arnaud and C. Chevillard
Index

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Reviews

"As this volume so capably demonstrates, genetic variation in cytokines, the messengers of the immune system, and their receptors is now recognized as playing an important role in disease susceptibility and outcome...This book is a timely anthology of knowledge, techniques as well as informed speculation…The chapters in this book represent an excellent and timely means of addressing questions related to the study of cytokine gene polymorphisms and will serve as an important reference work.."
- From the foreword by Grant Gallagher and Michael F. Seldin, Editors, "Genes and Immunity", March 2006