This up-to-date immunology textbook provides a clear and simple introduction to clinical and laboratory immunology for health professionals in training or in practice. It covers:
- essential basic immunology
- clinical immunology
- laboratory investigations of immunological disorders
- treatments used in immunological disorders.
Focusing on clinical problems seen in practice and including self-assessment questions and case histories to aid learning and understanding, this is an invaluable resource for all medical students, nurses, nutritionists, pharmacists and physiotherapists.
Table of Contents
Part 1: Basic Immunology 1. Introduction 2. Overview of Defence Mechanisms 3. Cells and Organs of the Immune System 4. Innate Immune Responses I 5. Innate Immune responses II – The Complement System 6. Innate Immune Responses III - Other Soluble Factors 7. Inflammation 8. What the Immune System Recognises 9. Human Leucocyte Antigen Modules 10. Antigen Presentation 11. How Does the Immune System See Antigen? 12. Lymphocyte Maturation 13. Immunoglobin structure 14. B Cell Activation 15. Immunoglobin Function 16. T Cell Receptor and Immune Repertoire 17. Helper T Cell Activation 18. Cytotoxic T Cells 19. The Mucosal Immune System 20. Initiation of the Immune Response 21. Maintenance of the Immune Response 22. Control of the Immune Response 23. Ontogeny of the Immune Response 24. Immune Responses to Infection 25. How Organisms Evade the Immune System 26. Consequences of Immune Response 27. Host Defence Against Tumours 28. Autoimmunity 29. Hypersensitivity 30. Atopy and Allergic Inflammation Self Assessment Part 2: Clinical Immunology 1. Clinical Manifestations of Atopy 2. Asthma 3. Urticaria and Angioedema 4. Food Allergy 5. Anaphylaxis 6. Other Types of Hypersensitivity Reactions 7. Immunodeficiency 8. Defects in Antibody - Mediated Immunity 9. Defects in T Cell-mediated Immunity 10. Neutrophil Disorders 11. Complement Deficiency 12. Defective Splenic Function 13. HIV 14. Autoimmunity 15. Autoimmune Endocrinopathies 16. Immune-mediated Haematological Conditions 17. Autoimmune Liver Disease 18. Immune-mediated Gastrointestinal Disorders 19. Immune-mediated Neurological Disease 20. Immune-mediated Skin Disease 21. Immune-mediated Renal Disease 22. Rheumatiod Disease and Spondylarthopathies 23. Connective Tissue Diseases 24. Vasculitides 25. Hypersensitivity Induced by Pathogens 26. Transplantation 27. Haemopoietic Stem Cell Transplantation 28. Solid Organ Transplantation 29. Lymphoid Malignances 30. Leukaemia and Lymphoma 31. Plasma Cell Diseases Self-Assessment Part 3: Immunotechniques and Diagnostic Tests Used in Clinical Immunology 1. Laboratory Tests in Clinical Immunology 2. Antibodies are Essential Tools in the Clinical Immunology Laboratory 3. Detection of Antibodies and Antigen 4. Autoantibody Profiles in Connective Tissue Diseases and Rheumatoid Diseases 5. Autoantibodies Associated with Vasculitic Syndromes and Renal Diseases 6. Autoantibodies Associated with Liver and Gastrointestinal Diseases 7. Autoantibodies Associated with Endocrine Diseases and Pernicious Anaemia 8. Other Organ-specific Autoimmunity 9. Measurement of the Acute Phase Response 10. Complement 11. Immunodeficiency 12. Abnormal Immunoglobulins 13. Angioedema: C1-Inhibitor Disorders 14. Allergy and Hypersensitivity 15. Transplantation 16. Immunophenotyping Leukaemias and Lymphomas 17. Direct Immunofluorescence Self Assessment Part 4: Treatment of Immunological Disorders 1. Principles of Immunosuppression 2. Corticosteroids 3. Immunosuppression (I) 4. Immunosuppression (II) 5. Therapeutic Antibody Production 6. Targeted Cell Depletion 7. Other Antibody Therapies 8. Immunoglobulin Replacement Therapy 9. High Dose Immunoglobin Therapy 10. Cytokines 11. Vaccination and Passive Immunisation 12. Plasmapheresis and Plasma Exchange 13. Management of Acute Allergic Reactions Self Assessment Clinical Immunology: Future Prospects
Mary Keogan is Consultant Clinical Immunologist at Beaumont and Mater Misericordiae Hospitals, Dublin and Senior Lecturer in Pathology, Royal College of Surgeons in Ireland. Eleanor Wallace is Medical Scientist in the Department of Immunology, Beaumont Hospital, Dublin. Paula Oâ€™Leary is Senior Tutor in the Department of Medicine, Cork University Hospital, Ireland.