As the third leading cause of death in the United States, stroke accounts for one in every fifteen deaths and is the major cause of disability in the country. Compiled by a renowned editorial team, this reference bridges the gap between basic science and patient care protocols, and collects 43 expertly written chapters that range from laboratory-based research on animal models to the progression, mechanisms, treatment, and prognosis of diseases such as subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), focal ischemic stroke, and global cerebral ischemia.
Table of Contents
SUBARACHNOID HEMORRHAGE (SAH). Animal Models of Subarachnoid Hemorrhage. Pathogenesis of Cerebral Aneurysmal Growth and Rupture. Pathogenesis of Cerebral Vasospasm. Surgical Management of Aneurysmal Subarachnoic Hemorrhage. Endovascular Management of a Patient After SAH. Intra-operative Management of Aneurysmal SAH. Medical Management of Subarachnoid Hemorrhage. Clinical Trials in SAH. Prognosis and Outcomes Following Aneurysmal Subarachnoid Hemorrhage. INTRACEREBRAL HEMORRHAGE (ICH). Animal Models of Intracerebral Hemorrhage. Pathophysiologic Mechanisms of Brain Injury Following Intracerebral. Surgical Management of an Intracerebral Hemorrhage. Medical Management of Intracerebral Hemorrhage. Clinical Trials in Intracerebral Hemorrhage. Prognosis and Outcomes Following Intracerebral Hemorrhage. FOCAL ISCHEMIC STROKE. Animal Models of Ischemic Stroke. Pathogenesis of Brain Injury Following Ischemic Stroke. Neuroimaging in Ischemic Stroke. Thrombolytic Therapy for Acute Ischemic Stroke. Medical Management of Acute Ischemic Stroke. Clinical Neuroprotectve Trials in Ischemic Stroke. Prognosis and Outcomes Following Ischemic Stroke. Venous Strokes and Venous Sinus Thrombosis. GLOBAL CEREBRAL ISCHEMIA. Animal Models of Global Cerebral Ischemia. Pathogenic Mechanisms of Brain Injury Following Global Cerebral Ischemia. Management of Brain Injury Following Cardiopulmonary Arrest. Prognosis and Neurologic Outcomes Following Cardiopulmonary Arrest. DOGMAS, CONTROVERSIES AND FUTURE DIRECTIONS. Failure of Neuroprotective Agents to Show Benefit in Clinical Trials. Ischemic Preconditioning. Therapeutic Potential of Hypothermia in Acute Stroke. Decompressive Hemicraniectomy for Stroke: An Old Therapy Revisited. Blood-Pressure Management in Subarachnoid Hemorrhage, Acute Ischemic Stroke, and Intracerebral Hemorrhage. Diagnosis and Treatment of Cerebral Arteriovenous Malformations (AVM). Endovascular Therapy for Carotid Stenosis. Acute Stroke Care Units: A Critical Appraisal. Telemedicine Applied to Stroke Care. Multimodality Neuromonitoring in Acute Stroke. Gender Differences in Stroke Pathobiology: Therapeutic Implications. Ultrasonography in the Management of Acute Stroke. Acute Stroke in the Young. Functional Recovery After Stroke with Cell-based Therapy. Brain Attack
"…The guiding philosophy of the present volume, assembled under the wise editorship of Drs. Bhardwaj, Alkayed, Kirsch, and Traystman, is to emphasize translationally important topic areas in cerebrovascular disease, where advances at the bench lead to advances at the bedside….Taken together, the contributors to this timely volume offer the reader a rich menu to savor. Clinician-investigators will benefit from its breadth and depth."
-Myron D. Ginsberg, M.D., University of Miami Miller School of Medicine, Florida, U.S.A. (from the foreword)